Reversal Reaction as a Manifestation of Immune Reconstitution Inflammatory Syndrome
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Molluscum Contagiosum as a Skin Manifestation of Immune Reconstitution Inflammatory Syndrome in an AIDS Patient Who Is Receiving HAART
Highly active antiretroviral therapy (HAART), which restores specific immune responses, may paradoxically cause an inflammatory reaction known as immune reconstitution inflammatory syndrome (IRIS). We report a patient with acquired immune deficiency syndrome, who presented Molluscum contagiosum as IRIS after HAART, the first case in Korea.
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White nose syndrome, caused by Geomyces destructans, has killed more than 5 million cave hibernating bats in eastern North America. During hibernation, the lack of inflammatory cell recruitment at the site of fungal infection and erosion is consistent with a temperature-induced inhibition of immune cell trafficking. This immune suppression allows G. destructans to colonize and erode the skin of...
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The goal of ARV therapy in immunocompromised HIV-infected individuals is immune reconstitution. However, an aberrant manifestation of this effect sometimes occurs. Immune reconstitution inflammatory syndrome (IRIS), also known as immune restoration disease, refers to a diseaseor pathogen-specific inflammatory response in HIV-infected patients that may be triggered after: Initiation or re-init...
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Immune reconstitution inflammatory syndrome (IRIS) is originally described in association with antiretroviral therapy (ART) for HIV infected patients. IRIS consists of a broad spectrum of inflammatory diseases, such as infectious inflammatory, neoplastic, and autoimmune diseases, that present after starting an effective ART, leading to CD4+ cells increase and plasma HIV-RNA reduction. IRIS refl...
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